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Therefore, some rejection problems commonly detected with organ transplants can be avoided [136]. Biomaterials are used to replace the affected cells with donor‘s cells or patient's own cells that have been previously treated with molecules such as hormones. One of the main forms to introduce these cells in the body is to encapsulate them into several matrices. Biocompatible and biodegradable materials are the principal materials used in tissue engineering because they allow cell adhesion and signal transmission.

Have obtained successful alginate-reinforced chitosan nanoparticles for transdermal delivery of rabeprazole, a potent proton pump inhibitor that controls the gastric acid secretion [79]. Lacerda et al. employed chitosan and sodium alginate based system to encapsulate rifampicin [80], showing also good results. Besides chitosan, other studies have demonstrated the effectiveness of new alginatebased formulations combined with other polymers on sustained drug release [81-85]. For instance, Shih-Feng et al.

Food Industry Bioactive peptides and antioxidants like vitamins, phenol, flavonoids and proanthocyanidins have also been encapsulated within alginate vehicles in order to preserve their biological activity against gastrointestinal degradation [117-119]. Bioactive peptides, for example, have an important role in diseases such as stress, obesity and cardiovascular disorders, acting as antihypertensive, antioxidant, and antithrombotic [120]. Sodium alginate is a good candidate for the encapsulation of these substances as it turns into insoluble alginic acid at stomach level, avoiding the diffusion of the encapsulated bioactive substances, while 30 A.

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